Agaricus Blazei Murril
Agaricus Blazei Murrill (ABM) a sister of the very common white button mushroom, the Agaricus bisporus. ABM has become more widely known since the 1960’s when it was ‘discovered’ in Brazil. The story goes, that a Japanese farmer and researcher came across a tribe which were free from diseases and with unusually long life-spans. The only unique thing he could see was that they incorporated ABM into their diet. It was brought to Japan due to alleged health effects and is widely used today in Oriental countries as an edible mushroom, it is considered a functional food, and a natural therapy in the form of a medicinal extract mostly for prevention and treatment of cancer.There is no doubt, that ABM is a particularly special medicinal mushroom. The Japanese started researching the mushroom in the late 1960s and began isolating active components soon afterwards. No other medicinal mushroom has such a high percentage of polysaccharides - particularly (1>3)(1>6)Beta-D-Glucans.
These specific glucans are found in all medicinal mushrooms and according to research they are mainly responsible for the immune balancing, anti-allergic and cholesterol/blood-pressure lowering effects. They are also effective in lowering the side effects of heavy medication such as chemo and radiotherapy, and might help in preventing metastasis as ABM also inhibits the enzyme aromatase, which is associated with the development of breast cancer.
Image from Kaiyuan Huang, Hesham R. El-Seedi, Baojun Xu.
Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill, Current Research in Food Science, Volume 5, 2022,
Key active compounds:
- Polysaccharides:
a-glucans and b-glucan
B-1,2-linked D-mannopyranosyl
Polyphenols
EXTRACTION METHOD:
Hot water extraction is necessary to unlock the full therapeutic potential
Interactions with pharmaceuticals
Interactions with herbs & supplements
Agaricus Blaze Murrill history
Agaricus Blazei Murrill is a mushroom originally native to a small village, named Piedade, in the highland areas of Atlantic forest, near Tauape, in the province of Sao Paolo, Brazil.
ABM has become more widely known since the1960’s when it was ‘discovered’ in Brazil by a Japanese farmer and researcher who sent it to Japan in 1965 for investigation. It was identified as ABM by the Belgian botanist Heinemann in 1967.
ABM is known in Brazil as Cogumelo De Sol (mushroom of the sun), cogumelo de Deus (mushroom of God) or cogumelo de vida (mushroom of life). In Japan it is know as Himematsutake (princess matsutake) and in China as Ji Song Rong.
The first historical description about the use of mushroom of Agaricus genus for medicinal purposes is probably described by Byzantine medical treatises in the Mediterranean area, from the 4th century AD to the 15th century AD by Orivasios and Apuleius for treating malignant ulcers of the larynx.
ABM use to be one of the most sought after medicinal mushroom but over the last decade has dropped in popularity
Some confusing technical history
The Agaricus Blaze Murrill mushroom was already known in the late 19th and early 20th century in the US, where it was very popular because of its excellent almond flavor and cultivated widely for the table. Colloquially known as the almond mushroom, it was officially named as Agaricus subrufescens since 1893.
After a few decades of success, the white button mushroom (Agaricus bisporus) took over its place as the most popular edible mushroom.
In the late 1940s the American mycologist W.A. Murrill discovered an interesting mushroom growing on the lawn of his friend R.W. Blaze in Florida. He did not recognize the species and, in honor of his friend, named it Agaricus Blazei. And now the confusion starts…
To cut a long story short, the mycologists were mixing up very similar looking mushrooms and in the end had to use DNA-profiling to put an end to all the quarrels.
Here are the mycological facts:The mushroom that received the name ‘Agaricus blazei Murrill‘ was in fact the ‘Agaricus silvaticus Schaeffer‘. It is not a medicinal mushroom.
The ‘Agaricus brasiliensis‘ (another name given to the actual medicinal mushroom in 2002) turned out to exist already (classified in 1830) and is also not a medicinal mushroom.
The actual medicinal mushroom incorrectly named Agaricus blazei/Agaricus brasiliensis should in fact be called Agaricus subrufescens, the oldest taxonomical name. However, this medicinal mushroom and its derivatives are still researched, marketed and sold under the name Agaricus blazei Murrill (ABM) and Agaricus brasiliensis worldwide. Very confusing.
Edibility
Agaricus Blazei Murrill features a slightly sweet, nutty flavor and can be used in any dish that calls for button or portobello mushrooms.
A note on Heavy Metals and Argaritine:
All Agaricus mushrooms (including the button-mushroom) absorb heavy metals like cadmium and lead very easily, therefore one should always verify the levels of these toxins before purchase. Never rely on the ‘organic’ label – this label does not guarantee the product is free from heavy metals, only pesticides. And since all mushrooms accumulate heavy metals from the soil and the air, high levels are very common. Only properly tested mushrooms should be considered.
Furthermore, all Agarics contain agaritine, a carcinogenic substance. However, the chance that agaritine is found in an extract of the mushroom is zero. It oxidises very fast upon storage, and totally degrades after 48 hours in water with exposure to air. It also decomposes very fast upon cooking (up to 90% reduction) and freezing (up to 75% reduction).
Since these processes are part of the standard extraction procedures it is quite clear that no agaritine will be found in extracts. Non-extracted ABM products (powdered fruiting bodies, myceliated biomass) can be a different story, though. We recommend to request a Certificate of Analysis from the supplier (not to be confused with a ‘spec sheet !).
Research articles
- "Agaricus blazei Murrill species has proven antitumor activity for some types of cancer, and the use of this natural product can improve health and increase the patients' immunity" (2022) Agaricus blazei Murrill mushroom: A review on the prevention and treatment of cancer
- "A. blazei is used to cure dermatitis, hepatitis, diabetes, therosclerosis, hyperlipidemia, and cancer in traditional medicine." (2021) Traditional Uses, Phytochemistry and Biological Activities of Agaricus blazei murrill: A Comprehensive Review
- " Sulfated modification of AbM polysaccharides can increase their anti-HIV pharmacological activity, which makes them promising alternative candidates as bioactive macromolecules for biomedical applications in HIV/AIDS." (2021) Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, Characterization and Anti-HIV Activity
- "The results suggested that ABM treatment could effectively reduce oxidative stress and contribute to pancreatic tissue recovery." (2020) The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin-induced diabetic rats
- "The fruiting body of AbM is rich in β-glucans, and the biological effect of AbM has originally been attributed to the immunomodulating effect of this polysaccharide, mainly through activation of the innate immune system" (2020) Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies
- The Mushroom Agaricus blazei Murill in Combination with Metformin and Gliclazide Improves Insulin Resistance in Type 2 Diabetes - A Randomized, Double-Blinded, and Placebo-Controlled Clinical Trial
- Effect of Agaricus blazei Murill on the Pulmonary Tissue of Animals with Streptozotocin-Induced Diabetes
- Agaricus blazei: cultivation and mycochemical contents
Mushroom Education Project 2024