
Maitake
Grifola frondosa

Maitake is a widespread edible and delicious fungus of the Northern Hemisphere, which is known around the world by many names. In English, it is called hen of the woods. The Chinese name translates to “grey tree flower” which is a perfect descriptor. The polypore grows in elegant clusters like a rosette, at the base of dead/dying hardwoods (including oaks, elms, maples, chestnuts, etc.), often perennially - meaning it often grows in the same place for several years in succession!
It seems the powerful medicinal effects of this fungus have long been treasured. Traditional use in Asia is documented as far back as the Han Dynasty (206-210 CE), in the Shen Nong Ben Cao Jing (Divine Farmer's Classic of Materia Medica). It was utilised to boost Qi, calm the mind and nerves, and improve the health of the spleen, stomach, liver and lungs.
Maitake contains a broad range of chemical constituents with potential clinical value including coumarins, terpene lactones, flavonoids, organic acids, alkaloids, steroids, and triterpenes. However, most studies are only focused on the polysaccharide components of Maitake. Hopefully, future research will reveal more about the beneficial effects of this mushroom’s complex chemistry, just like we have with Lion’s Mane, Reishi and Cordyceps.
Maitake does produce a remarkably complex array of pure and protein bound polysaccharides, predominately composed of glucose, but also galactose, mannose, fucose, trehalose and ribose. Some of these are unique to Maitake.
In 1955 Japanese researchers identified Grifola frondosa polysaccharide (GFP) or the D-fraction (as it is commonly referred to) as the main biologically active constituent, found in both fruiting bodies and mycelia. The D-fraction is a protein-bound polysaccharide, consisting of a few types of β-glucans (the technical names and structures of these β-glucans can be a bit confusing, so I’ve deliberately kept it simple). To date there are at least 47 bioactive polysaccharides discovered in Maitake. Various techniques are utilised to separate out and purify other active polysaccharide fractions for medicinal use and ongoing research, such as MD-fraction, MZ-fraction, SX-fraction and Grifolans.
Key Actions:
- Anti-cancer (adjuvant)
Anti-diabetic - Anti-hyperglycaemic
- Anti-obesogenic
- Antioxidant
- Anti-inflammatiry
- Immunomodulatory
- Hepatoprotective
- Lipid-modulatory
- Ovulatory stimulant
- Neuroprotective
- Prebiotic
Key Indications:
- Cancer adjuvant therapy
- Common cold/influenza
- Diabetes and hyperglycemia
- Dysbiosis
- Immune system suppression
- Hyperlipidemia
- Infections (bacterial, viral)
- Mercury or metal toxicity
- Metabolic syndrome
- Non-alcoholic fatty liver disease
- Polycystic ovary syndrome (PCOS)
- Neurodegenerative diseases

Key active compounds:
Polysaccharides - over 47 biactive polysaccharides have been isolated from Maitake, the most important medically being the Grifola Frondosa polysaccharide
D-fractions
- Anti-cancer (adjuvant)
EXTRACTION METHOD:
Hot water extraction is necessary to unlock the full therapeutic potential:
Interactions with pharmaceuticals
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Maitake mushroom might lower blood sugar levels. Taking maitake mushroom along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating=Moderate Be cautious with this combination.
Maitake mushroom might lower blood pressure. Taking maitake mushroom along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Warfarin (Coumadin)
Interaction Rating=Moderate Be cautious with this combination.
Maitake mushroom might increase the blood thinning effects of warfarin and potentially increase the chance of bleeding. Your healthcare provider may need to monitor you more often if you take maitake mushroom along with warfarin. The dose of your warfarin medication may need to be changed.
Interactions with herbs & supplements
Herbs and supplements that might lower blood pressure: Maitake mushroom might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.
Herbs and supplements that might lower blood sugar: Maitake mushroom might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Interactions with foods
There are no known interactions with foods.
Chinese Medicine perspective
Meridians: Spleen, Kidneys, Lungs, Large Intestine
Key Actions: Tonifies Spleen Qi, Tonifies the Stomach, Tonifies the Kidneys, Calms Shen, Promote Urination, Reduce Inflammation
Medicinal Uses: Urinary bladder weakness, weight gain, frailty, fatigue, oedemas, longevity, breast cancer, metabolic syndrome, high blood pressure, type 2 diabetes, cholesterol, anxiety, haemorrhoids, support immune function.
Maitake history
In Japan and China, Matiake has been highly valued not only as a culinary delicacy but also for its medicinal properties for more than 3000 years. Traditionally, it was used in Eastern medicine to enhance the immune system, lower blood pressure, and support overall health.
Maitake is the Japanese name, which translates literally as “dancing mushroom”. It is named thus for the celebration that would traditionally ensue upon finding a specimen, for Maitake were once worth their weight in silver! During Japan's feudal era, maitake was used as currency; the daimyo, or provincial nobles, would exchange maitake for its weight in silver from the shogun, the military ruler of Japan.
Maikate has only been cultivated commercially since the early 1980s, before which it was laboriously harvested by hand in the wild. Today, it is one of the most widely used mushrooms in Japanese cuisine due to its pleasant aroma, but it is also important as a vital mushroom in Asia.
Modern scientific research has confirmed many of its health benefits, making it a popular supplement in contemporary herbal medicine and a sought-after ingredient in gourmet cuisine worldwide.
Geographic location
Native to China, northeastern Japan, North America and parts of Europe, Maitake mushrooms grow in temperate hardwood forests where they feed upon the dead roots of older trees, in particular oaks but also elms and occasionally maples. They are polypore mushrooms, meaning they have pores or tubes on the underside, as opposed to gills.
Maitake grows as masses of small brownish-grey, fan-shaped caps fused onto a single, branching stalk. In Europe, Maitake is almost impossible to find in the wild, partly because its substrate has become so rare, because old oaks have also become a rarity in Europe.
Edibility
When cooked, maitake mushrooms exhibit a rich, earthy, and savoury flavour with a hint of umami. Their taste has been described as a delightful fusion of woodsy and meaty notes, with a subtle sweetness.
In addition to their unique flavour, maitake mushrooms also possess a remarkable texture that further enhances their culinary appeal. When cooked, they develop a tender yet slightly chewy consistency with a satisfying, meaty mouthfeel. This textural quality makes them an ideal addition to a wide range of dishes, including soups, stews, stir-fries, and even as a topping for pizzas or flatbreads.
Research articles
- "With increasing public concern about health threats from food contamination, environmental pollution and new infectious organisms such as the COVID-19 virus, the protection of human health through the immunomodulatory and health-promoting functions of G. frondosa constituents is even more attractive and promising." (2021) Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake)
- "Grifola frondosa is a potential candidate for tumor treatment and clinical trials." (2021) Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment
- "Grifola frondosa (GE) extract has been demonstrated to represent an important source of polysaccharides and phenolic compounds with in vitro antioxidant activity. The extract of GE was considered nongenotoxic in a preliminary SOS/umu screening test. The in vivo evaluation demonstrated that treatment with GE significantly reduced the lipid content in C. elegans, decreased the intracellular ROS accumulation and the aging-related lipofuscin pigment, and increased the nematode lifespan" (2021) Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXOand SKN-1/NRF2 Signalling Pathways
- "These metabolites exerted positive effects on colorectal cell lines, in particular protecting from reactive oxygen species." (2021) Prebiotic Effect of Maitake Extract on a Probiotic Consortium and Its Action after Microbial Fermentation on Colorectal Cell Lines
- "In conclusion, from the literature it seems possible that the related medicinal Basidiomycetes mushrooms, Agaricus blazei Murill, Hericium Erinaceus and Grigola Frondosa would have merit as prophylactic or therapeutic add‐on remedies in COVID‐19 infection, especially as countermeasures against a pneumococcal superinfection, even when caused by multi‐resistant bacteria, as well as for the immune overreaction and damaging inflammation that occurs with COVID‐19 attack. (2020) Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?
- "Maitake mushroom beta-glucan, a dietary supplement, stimulates hematopoietic progenitor cell differentiation, granulocyte colony-stimulating factor production, and recovery of peripheral blood leukocytes after bone marrow injury." (2015) Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study
- " Maitake Grifola extract alone may induce ovulation in PCOS patients and may be useful as an adjunct therapy for patients who failed first-line CC treatment." (2010) Maitake Mushroom Grifola frondosa Extract Induces Ovulation in Patients with Polycystic Ovary Syndrome: A Possible Monotherapy and a Combination Therapy After Failure with First-Line Clomiphene Citrate
- Can Maitake MD-Fraction Aid Cancer Patients
- Immunostimulating properties of two different β-glucans isolated from Maitake mushroom
Mushroom Education Project 2025

