Chaga
Inonotus obliquus
Chaga is a parasitic fungus that predominantly infects Birch trees. Unlike other common mushrooms, the fruiting body is rarely seen and rarely, if ever, used. Because the fruiting event is rare, occurring within a host tree towards the end of its life, the details are still wrapped in mystery. What is used in traditional medicines and modern supplements is the ‘sclerotia’ or ‘canker’ which consists primarily of wood lignans from the host tree and mycelium of the invasive fungus. Therefore, as Chaga almost exclusively grows on birch trees, it will also contain birch compounds including betulin and betulinic acid.
Many of Chaga’s therapeutically interesting metabolites appear to develop only as a side effect of the harsh environment which it tends to favour and the on-going struggle with the trees' defence systems. Cultivated Chaga is not involved in a struggle for survival, and therefore will not develop these secondary metabolites.
Key Actions:
- Anticancer adjuvant
- Antidiabetic
- Anti-inflammatory
- Antioxidant
- Anti-psoriatic
- Anti-viral
- Cardioprotective
- Gastrointestinoprotective
- Hepatoprotective
- Lipid-modulatory
- Microbiota-modulatory
- Nephroprotective
- Neuroprotective
Key Indications:
- Cancer and tumour (adjuvant)
- Cardiovascular disease
- Diabetes
- Dysbiosis and leaky gut
- Fatty liver disease
- Gastrointestinal inflammation
- Metabolic syndrome
- Neuralgia/neuroinflammation
- Obesity
Key active compounds:
Polysaccharides - Beta Glucans, Heteroglycans, Proteoglucans.
Terpenes and Terpenoids - more than 40 lanostane-type tripernoids have been isolated
Melanin - high amounts, primarily allomellanins
Phenolic compounds - Philligridin Dihydroxybenzalacetone, Flavonoids
Sterols: ergosterols and derivatives, Sitosterol, stigmasterol and other phytosterols
Proteins: Lectins
Other compounds: Oxalates
EXTRACTION METHOD:
Dual extraction is necessary to unlock the full therapeutic potential:
- hot water extraction to unlock the water soluble beta glucans
- alcohol extraction to unlock the secondary metabolites such as triterpenes
Interactions with pharmaceuticals
Interactions with herbs & supplements
Chinese Medicine perspective
About Chaga cultivation
The known use of Chaga dates back 5,300 years ago when Otzi the Iceman (a well-preserved mummy discovered in the Austrian Alps in 1991), was found with Chaga in his pouch.
The word ‘Chaga’ is derived from the Khanty (formerly called the Ostyak) language, a tribe inhabiting Western Siberia. Chaga was and is still used by the Khanty for general well-being, internal cleaning (detoxing) and curing and preventing disease in general, but in particular for liver problems, heart problems, tuberculosis and to get rid of parasitic worms. It was prepared as a tea. (method of preparation: cut up dried Chaga, put it into boiling water, boil for several minutes.) Three cm3 were used for 2.5L of tea, and the tea was drunk until the ailment was cured.
Khanty men, Vakh river, 1898 >
The Khanty also used Chaga to make ‘soap water‘. To make ‘soap water‘ the fungus was first put into the fire. When it turned red (like smouldering charcoal) it was put into a bucket of hot water and then stirred until it broke into small pieces. The black water thus obtained has a strong cleaning and disinfecting ability.This ‘soap water‘ was used to wash the genitals of women during menstruation and after birth; sometimes new-born babies were also washed.
One Khanty compared it to the effect of a KMnO4 solution (potassium permanganate; a disinfectant used in Russia to wash new-borns the first three months after their birth) and stated that women who washed themselves with such water, never took ill. In older times it had been used instead of soap to wash the hands, feet and sometimes also the whole body. Chaga was also burned and the smoke was inhaled; its purpose was ritual cleaning.
The Ainu people
An ethnic group indigenous to Hokkaido, the Kuri islands and Sahkhalin used to drink Chaga tea to treat stomach pain and inflammations. Another use was filling a pipe with powdered Chaga, lit and smoke it during religious ceremonies. The leader of the ceremony inhaled the smoke and then passed the pipe to his neighbor. The pipe continued circulating until all the participants had smoked it. This ritual was described as ‘consuming the smoke‘. Although the medicinal effects of the smoke are unknown, this tradition shows that Chaga was highly regarded.
Several native tribes (the Woodland Cree, the Gitksan, the Wet’suwet’en and the Tenaina, e.g.)in North-America/Canada knew and used the Chaga fungus.
After WWII Chaga research really took off in Russia, fueled by the reputation Chaga had built in folk medicine during the past centuries. This resulted in an official entry in the USSR State Pharmacopeia. With such interesting results being published, the rest of the world soon jumped on the Chaga bandwagon.
Records of medicinal use of Chaga can be found in texts including Greek text Hippocratic Corpus (5th century BC) and Islamic text Avicenna (Cannon of Medicine).
Research articles
- "Inonotus obliquus exhibited enormous potential in immunity enhancement, and antitumor, antioxidant, anti-fatigue, hypoglycemic, and hypolipidemic activity, providing an alternative way for treatment of cancer and diabetes." (2021) Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application
- "Chaga mushroom shows promise in interacting with the viral spike protein and can be further explored in clinical settings that can bolster the current treatment regime for SARS‐CoV‐2. This will assist in developing natural anti‐coronavirus therapeutics in future that can greatly supplement the use of current anti‐SARS‐CoV‐2 drugs." (2021) Targeting SARS‐CoV‐2 with Chaga mushroom: An in silico study toward developing a natural antiviral compound
- "The findings uncovered the benefits of Chaga mushroom on DNA damage and advocated its use and development as a natural therapeutic. " (2021) Chaga mushroom (Inonotus obliquus) polysaccharides exhibit genoprotective effects in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes
- "...inonotusols I and L presented the most potent inhibitory effects on inducible nitric oxide synthase (iNOS) and NO production without any significant cytotoxicity" (2021) Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus
- "It provides the theoretical basis and evidence for preventing and treating T. gondii infection with Inonotus obliquus" (2021) Inhibitory Effects of Inonotus obliquus Polysaccharide on Inflammatory Response in Toxoplasma gondii-Infected RAW264.7 Macrophages
- "...for those who are in the process of chemotherapy administration of the fungus will not only chemosensitize the tumor cells and thereby increasing the chemotherapeutic effects, but also help to restore the compromised immunity and protect against ulcerative GI tract damage and other side-effects induced by chemotherapy." (2020) Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus
- "Data presented here supports that histamine induced inflammation is a major disruptor of junctional integrity, and highlights the important anti-inflammatory properties of Inonotus obliquus" (2019) Inonotus obliquus attenuates histamine-induced microvascular inflammation
- Treatment of psoriasis with Chaga
- Antioxidant Small Phenolic Ingredients in Inonotus obliquus
- Identification of Inonotus obliquus (Chaga) and Analysis of Antioxidation and Antitumor Activities of Polysaccharides
- Sterol composition in field-grown and cultured mycelia of Inonotus Obliquus
- Chemical and pharmacological properties of dry extract from black birch fungus
- Antitumor Activity of Water Extract of a Mushroom, Inonotus obliquus, against HT-29 Human Colon Cancer Cells
- Antioxidant effect of Inonotus obliquu
- Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract
- Analysis of an aqueous extract of Inonotus Obliquus (Chaga)
- The Anticancer Effect of Inonotus obliquus Pilat (Chaga) Processed by Nanomill Technology In vivo
- Chemical and medico-biological properties of Chaga
- Fungal medicine, Fuscoporia obliqua (Chaga), as a traditional herbal medicine: its bioactivities, in vivo testing and medicinal effects
- Phenolic compounds from Inonotus obliquus and their immune-stimulating effects
Mushroom Education Project 2024